[CAS NO. 84176-65-8] Antimalarial agent 1

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PRODUCTS SPECIFICATIONS [84176-65-8]

Catalog

HY-W009109

Brand

MCE

CAS

84176-65-8

DESCRIPTION [84176-65-8]

Overview

MDL	MFCD00012733
Molecular Weight	344.31
Molecular Formula	C12H21N6O4P
SMILES	NC1=NC(N)=C2N=C(C(C(C)C)=NC2=N1)C(C)C.O=P(O)(O)O

For research use only. We do not sell to patients.

Summary

Antimalarial agent 1 is a potent antimalarial drug ^[1] .

In Vitro

Antimalarial agent 1 has an antimalarial index of 1:40, when tested against Plasmodium gallinaceum ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 363.04 mM ; Need ultrasonic)

H ₂ O : 2 mg/mL ( 5.81 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9044 mL	14.5218 mL	29.0436 mL
5 mM	0.5809 mL	2.9044 mL	5.8087 mL
10 mM	0.2904 mL	1.4522 mL	2.9044 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] MCCONNACHIE EW, et al. The action of 2:4-diamino-6:7-diisopropylpteridine on normal, proguanil- and sulphadiazine-resistant strains of . arasitology. 1953 Jan;42(3-4):272-6.

Synonyms

2,4-Pteridinediamine, 6,7-bis(1-methylethyl)-, phosphate (1:1)

Pteridine, 2,4-diamino-6,7-diisopropyl-, phosphate

NSC 98771

2,4-Diamino-6,7-diisopropylpteridine Phosphate