[CAS NO. 84783-01-7] K-Ras-IN-1

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PRODUCTS SPECIFICATIONS [84783-01-7]

Catalog

HY-18674

Brand

MCE

CAS

84783-01-7

DESCRIPTION [84783-01-7]

Overview

MDL	MFCD02193415
Molecular Weight	207.29
Molecular Formula	C11H13NOS
SMILES	S=C(C1=CC=CC=C1O)N2CCCC2

For research use only. We do not sell to patients.

Summary

K-Ras-IN-1 is a K-Ras inhibitor. K-Ras-IN-1 binds to K-Ras (WT), K-Ras (G12D), K-Ras (G12V), and H-Ras . K-Ras-IN-1 has potential for the research of pancreatic, colon and lung carcinomas ^[1] ^[2] .

IC50 & Target

K-Ras ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 482.42 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8242 mL	24.1208 mL	48.2416 mL
5 mM	0.9648 mL	4.8242 mL	9.6483 mL
10 mM	0.4824 mL	2.4121 mL	4.8242 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution

* All of the co-solvents are available by MCE.