[CAS NO. 84878-61-5] Maduramicin ammonium
PRODUCTS SPECIFICATIONS [84878-61-5]
DESCRIPTION [84878-61-5]
Overview
| MDL | MFCD00865282 |
|---|---|
| Molecular Weight | 934.16 |
| Molecular Formula | C47H83NO17 |
| SMILES | C[C@]1([C@]2([H])O[C@](C)([C@@]3([H])[C@H](C[C@@]([C@@]4([H])O[C@](O)([C@H](C)C[C@@H]4C)C)([H])O3)O[C@]5([H])C[C@@H]([C@@H](OC)[C@H](C)O5)OC)CC2)O[C@]6(O[C@]([C@H](C)[C@@H](O)C6)([H])[C@H]([C@@]7([H])[C@@H]([C@H]([C@H](C)[C@](CC(O)=O)(O)O7)OC)OC)C)CC1.N |
Summary
Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra . Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp. , E. adenoeides , E. gallopavonis , and E. dispersa infection [1] . Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways [2] .
IC50 & Target
IC50: bacterial; apoptosis [1]
Appearance
Solid
Source
Streptomyces
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 26.76 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.0705 mL | 5.3524 mL | 10.7048 mL |
| 5 mM | 0.2141 mL | 1.0705 mL | 2.1410 mL |
| 10 mM | 0.1070 mL | 0.5352 mL | 1.0705 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution
References
- [1] McDougald LR, et al. Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.Avian Dis. 1990 Jul-Sep;34(3):634-8.
- [2] Gao X, et al.Maduramicin induces apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.Toxicol In Vitro. 2018 Aug;50:190-200.