[CAS NO. 85081-18-1] NBI-98782

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PRODUCTS SPECIFICATIONS [85081-18-1]

Catalog

HY-15793

Brand

MCE

CAS

85081-18-1

DESCRIPTION [85081-18-1]

Overview

MDL	MFCD08061467
Molecular Weight	319.44
Molecular Formula	C19H29NO3
SMILES	COC(C=C1CCN2C[C@@H](CC(C)C)[C@@H]3O)=C(C=C1[C@]2(C3)[H])OC

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Crit Rev Anal Chem. 2021 Mar 10;1-15.

Summary

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM. IC50 value: 0.97± 0.48 nM [1] Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 104.34 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1305 mL	15.6524 mL	31.3048 mL
5 mM	0.6261 mL	3.1305 mL	6.2610 mL
10 mM	0.3130 mL	1.5652 mL	3.1305 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kilbourn M, et al. Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific. Eur J Pharmacol. 1995 May 24;278(3):249-52.