[CAS NO. 852146-73-7] KR-32568
PRODUCTS SPECIFICATIONS [852146-73-7]
DESCRIPTION [852146-73-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 261.25 |
| Molecular Formula | C13H12FN3O2 |
| SMILES | FC1=CC=C(C(C2=CC=C(O2)C(NC(N)=N)=O)=C1)C |
Summary
IC50 & Target
IC50: 230 nM (NHE-1) [2]
In Vitro
KR-32568 (10 nM-1 μM) inhibits NHE-1-mediated platelet swelling induced by intracellular acidifi cation of rabbit platelet-rich plasma in a concentration-dependent manner, with the IC 50 value of 24 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
KR-32568 (0.1-1.0 mg/kg; i.v.; once) exert potent cardioprotective effects in rats, such as reduces infarct size, and significantly reduces the total number of ventricular premature beats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats (350-380 g) bearing 30 min ischemia/2.5 h reperfusion heart injury [1] |
| Dosage: | 0.1 mg/kg and 1.0 mg/kg |
| Administration: | i.v.; once |
| Result: | Exerted potent cardioprotective effects in rats. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44.
- [2] Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.