[CAS NO. 854171-35-0] IndirubinDerivativeE804
PRODUCTS SPECIFICATIONS [854171-35-0]
DESCRIPTION [854171-35-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 365.38 |
| Molecular Formula | C20H19N3O4 |
| SMILES | O=C1NC2=C(C=CC=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OCCC(O)CO |
Summary
Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R) , with an IC 50 of 0.65 μM for IGF1R.
IC50 & Target
IC50: 0.65 μM (IGF1R) [1] .
In Vitro
Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC 50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC 50 of 0.23 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 342.11 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7369 mL | 13.6844 mL | 27.3688 mL |
| 5 mM | 0.5474 mL | 2.7369 mL | 5.4738 mL |
| 10 mM | 0.2737 mL | 1.3684 mL | 2.7369 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (5.69 mM); Suspended solution; Need ultrasonic