[CAS NO. 868359-05-1] WAY-213613
PRODUCTS SPECIFICATIONS [868359-05-1]
DESCRIPTION [868359-05-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 415.19 |
| Molecular Formula | C16H13BrF2N2O4 |
| SMILES | BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2 |
2 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 5004 nM (EAAT1); 85 nM (EAAT2); 3787 nM (EAAT3) [1]
In Vitro
WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC
50
values of 5004 nM, 85 nM and 3787 nM, respectively
[1]
.
WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[
3
H] glutamate uptake with K
i
values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively
[1]
.
WAY-213613 (0-100 μM) produces a concentration-dependent
block of glutamate-induced currents in EAAT1-, EAAT2- or
EAAT3-injected oocytes, with IC
50
values of 48, 0.13 and 4.0 μM, respectively
[1]
.
WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
- [2] Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.
Synonyms