[CAS NO. 871837-60-4] DRAK2-IN-1
PRODUCTS SPECIFICATIONS [871837-60-4]
DESCRIPTION [871837-60-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 376.41 |
| Molecular Formula | C21H20N4O3 |
| SMILES | CCCCC(NC1=CC2=C(NC(/C2=C3NC4=C(C=CC=C4)C\3=N\O)=O)C=C1)=O |
Summary
DRAK2-IN-1, compound 16, is a potent, selective and ATP-competitive DRAK2 inhibitor with IC 50 and K i values of 3 nM and 0.26 nM, respectively. DRAK2-IN-1 also has inbitory effect on DRAK1 ( IC 50 =51 nM) [1] .
IC50 & Target
IC50: 3 nM (DRAK2); 51 nM (DRAK1); 1.8 μM (DRPK2); 2.3 μM (DRAK2); 1.8 μM (DRPK3) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 265.67 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6567 mL | 13.2834 mL | 26.5668 mL |
| 5 mM | 0.5313 mL | 2.6567 mL | 5.3134 mL |
| 10 mM | 0.2657 mL | 1.3283 mL | 2.6567 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (5.53 mM); Suspended solution; Need ultrasonic