[CAS NO. 87239-81-4] Cefpodoxime Proxetil

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PRODUCTS SPECIFICATIONS [87239-81-4]

Catalog

HY-N7101

Brand

MCE

CAS

87239-81-4

DESCRIPTION [87239-81-4]

Overview

MDL	MFCD00865088
Molecular Weight	557.60
Molecular Formula	C21H27N5O9S2
SMILES	O=C(C(N12)=C(COC)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)OC(OC(OC(C)C)=O)C

For research use only. We do not sell to patients.

Summary

Cefpodoxime Proxetil is a first oral and broad spectrum antibiotic that belongs to the third generation of cephalosporin. Cefpodoxime Proxetil binds to penicillin binding proteins ( PBPs ), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis ^[1] .

IC50 & Target

β-lactam

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03491748	Entasis Therapeutics	Healthy Volunteers	March 16, 2018	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 224.18 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7934 mL	8.9670 mL	17.9340 mL
5 mM	0.3587 mL	1.7934 mL	3.5868 mL
10 mM	0.1793 mL	0.8967 mL	1.7934 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.73 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.73 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.73 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Iqbal S, et al. In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers. Pak J Pharm Sci. 2019 Mar;32(2 (Supplementary)):881-887.

Synonyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, [6R-[6α,7β(Z)]]-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-

CS 807 (pharmaceutical)

CS 807

Cefpodoxime proxetil

U 76252

Antibiotic CS 807

RU 51807

Banan

(RS)-1-(Isopropoxycarbonyloxy)ethyl (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-[(Z)-(methoxyimino]acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Orelox

Vantin

Otreon

Cefodox

Cephpodoxime proxetil

Cepodem

Cefoprox

Cefoflam

Simplicef