[CAS NO. 873305-35-2] AIM-100

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PRODUCTS SPECIFICATIONS [873305-35-2]

Catalog

HY-15290

Brand

MCE

CAS

873305-35-2

DESCRIPTION [873305-35-2]

Overview

MDL	MFCD22417088
Molecular Weight	371.43
Molecular Formula	C23H21N3O2
SMILES	C1(C2=C(C3=CC=CC=C3)OC4=C2C(NC[C@@H]5CCCO5)=NC=N4)=CC=CC=C1

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

AIM-100 is a potent and selective Ack1 inhibitor with an IC ₅₀ of 21.58 nM. AIM-100 also inhibits Tyr ²⁶⁷ phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect ^[1] ^[2] .

IC50 & Target

IC50: 21.58 nM (Ack1) ^[2]

In Vitro

AIM-100 (2-10 μM; 48 hours) treatment not only inhibits Ack1 activation but also suppresses AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase. AIM-100 not only inhibits Ack1/AKT Tyr-phosphorylation but also suppressed growth of cell lines derived from pancreatic, breast, and lung tumors ^[1] .
The Ack1 inhibitor AIM-100 not only inhibited Ack1 activity but also was able to suppress AR Tyr ²⁶⁷ phosphorylation and its recruitment to the ataxia-telangiectasia mutated kinase (ATM) enhancer ^[2] .
AIM-100 is able to suppress pTyr ²⁶⁷ -AR phosphorylation, binding of androgen receptor (AR) to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In male nude castrated mice, AIM-100 (4 mg/kg) suppresses growth of radioresistant castration-resistant prostate cancer (CRPC) xenograft tumors by decreasing ataxia-telangiectasia mutated kinase (ATM) expression ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 134.61 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6923 mL	13.4615 mL	26.9230 mL
5 mM	0.5385 mL	2.6923 mL	5.3846 mL
10 mM	0.2692 mL	1.3461 mL	2.6923 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution

* All of the co-solvents are available by MCE.