[CAS NO. 877-43-0] 2,6-Dimethylquinoline

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PRODUCTS SPECIFICATIONS [877-43-0]

Catalog

HY-W010195

Brand

MCE

CAS

877-43-0

DESCRIPTION [877-43-0]

Overview

MDL	MFCD00006762
Molecular Weight	157.22
Molecular Formula	C11H11N
SMILES	CC1=CC2=C(C=C1)N=C(C)C=C2

For research use only. We do not sell to patients.

Summary

2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum , is a CYP1A2 inhibitor with an IC ₅₀ of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC ₅₀ of 480 µM ^[1] ^[2] ^[3] .

IC50 & Target

CYP1A2

3.3 μM (IC ₅₀ )

CYP2B6

480 μM (IC ₅₀ )

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 636.05 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3605 mL	31.8026 mL	63.6051 mL
5 mM	1.2721 mL	6.3605 mL	12.7210 mL
10 mM	0.6361 mL	3.1803 mL	6.3605 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (15.90 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (15.90 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (15.90 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Quinoline, 2,6-dimethyl-

2,6-Dimethylquinoline

6-Methylquinaldine

p-Toluquinaldine

NSC 1782