[CAS NO. 88-14-2] 2-Furoic acid
PRODUCTS SPECIFICATIONS [88-14-2]
DESCRIPTION [88-14-2]
Overview
| MDL | MFCD00003238 |
|---|---|
| Molecular Weight | 112.08 |
| Molecular Formula | C5H4O3 |
| SMILES | O=C(C1=CC=CO1)O |
Summary
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation [1] . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats [2] .
IC50 & Target
|
Human Endogenous Metabolite |
In Vivo
2-Furoic acid significantly reduces serum cholesterol and serum triglyceride levels
[2]
.
2-Furoic acid also lowers the liver and small intestine ATP dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase and heparin induced lipoprotein lipase activities
[2]
.
2-Furoic acid shows the LD
50
of 250 mg/kg i.p. in the acute toxicity studies in mice
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Saccharomyces cerevisiae
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 892.22 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 8.9222 mL | 44.6110 mL | 89.2220 mL |
| 5 mM | 1.7844 mL | 8.9222 mL | 17.8444 mL |
| 10 mM | 0.8922 mL | 4.4611 mL | 8.9222 mL |
References
- [1] Wordofa GG, et al. Tolerance and metabolic response of Pseudomonas taiwanensis VLB120 towards biomass hydrolysate-derived inhibitors. Biotechnol Biofuels. 2018 Jul 19;11:199.
- [2] Hall IH, et al. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch Pharm (Weinheim). 1993 Jan;326(1):15-23.
Synonyms