[CAS NO. 88-58-4] 2,5-Di-tert-butylhydroquinone

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PRODUCTS SPECIFICATIONS [88-58-4]

Catalog

HY-W012399

Brand

MCE

CAS

88-58-4

DESCRIPTION [88-58-4]

Overview

MDL	MFCD00008825
Molecular Weight	222.32
Molecular Formula	C14H22O2
SMILES	OC1=CC(C(C)(C)C)=C(O)C=C1C(C)(C)C

For research use only. We do not sell to patients.

Summary

2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 ( IC ₅₀ =1.8 and 14.1 μM for 5-LO and COX-2 , respectively) ^[1] .

IC50 & Target

5-LO

1.8 μM (IC ₅₀ )

COX-2

14.1 μM (IC ₅₀ )

In Vitro

DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 449.80 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4980 mL	22.4901 mL	44.9802 mL
5 mM	0.8996 mL	4.4980 mL	8.9960 mL
10 mM	0.4498 mL	2.2490 mL	4.4980 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.25 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.

Synonyms

1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-

Hydroquinone, 2,5-di-tert-butyl-

2,5-Bis(1,1-dimethylethyl)-1,4-benzenediol

Santovar O

Dibug

DTBHQ

2,5-Di-tert-butylquinol

Nocrac NS 7

Antage DBH

Naugard 451

DBH

1,4-Dihydroxy-2,5-di-tert-butylbenzene

2,5-Di-tert-butyl-1,4-hydroquinone

Nonflex Alba

2,5-Di-tert-butyl-1,4-benzohydroquinone

2,5-Di-tert-butylhydroquinone

2,5-Di-tert-butyl-1,4-benzenediol

NSC 11

NSC 9886

BHQ

2,5-Dihydroxy-1,4-di-tert-butylbenzene

DBHQ

Alba

2,5-Di-tert-butyl-1,4-dihydroxybenzene

3,6-Di-tert-butylhydroquinone

Antioxidant NS 7

Antioxidant Alba

Antioxidant DBH

2,5-Ditert-butylbenzene-1,4-diol