[CAS NO. 88110-89-8] Ganciclovirmono-O-acetate

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PRODUCTS SPECIFICATIONS [88110-89-8]

Catalog

HY-41344

Brand

MCE

CAS

88110-89-8

DESCRIPTION [88110-89-8]

Overview

MDL	MFCD09840659
Molecular Weight	297.27
Molecular Formula	C11H15N5O5
SMILES	O=C1N=C(N)NC2=C1N=CN2COC(COC(C)=O)CO

For research use only. We do not sell to patients.

Summary

Ganciclovir mono-O-acetate is a derivative of Ganciclovir. Ganciclovir, a nucleoside analogue, is an orally active antiviral agent with activity against CMV ^[1] .

In Vitro

Ganciclovir mono-o-acetate is a mono-O-acetate ester of Ganciclovir.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 168.20 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3639 mL	16.8197 mL	33.6395 mL
5 mM	0.6728 mL	3.3639 mL	6.7279 mL
10 mM	0.3364 mL	1.6820 mL	3.3639 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.41 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (8.41 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Faulds D, et al. Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39(4):597-638.

Synonyms

6H-Purin-6-one, 9-[[2-(acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-

9-[[2-(Acetyloxy)-1-(hydroxymethyl)ethoxy]methyl]-2-amino-1,9-dihydro-6H-purin-6-one

2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-acetoxy-1-propanol

3-Hydroxy-2-((2-imino-6-oxo-2,3-dihydro-1H-purin-9(6H)-yl)methoxy)propyl acetate