[CAS NO. 882366-16-7] SBI-115

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PRODUCTS SPECIFICATIONS [882366-16-7]

Catalog

HY-111534

Brand

MCE

CAS

882366-16-7

DESCRIPTION [882366-16-7]

Overview

MDL	MFCD07537427
Molecular Weight	340.78
Molecular Formula	C14H13ClN2O4S
SMILES	O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5 ^[1] .

In Vitro

SBI-115 (100-200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[1]

Cell Line:	shRNA-transfected ADPKD cholangiocytes
Concentration:	100, 200 µM
Incubation Time:	24 hours
Result:	Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL ( 440.17 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9344 mL	14.6722 mL	29.3444 mL
5 mM	0.5869 mL	2.9344 mL	5.8689 mL
10 mM	0.2934 mL	1.4672 mL	2.9344 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218.