[CAS NO. 883-84-1] 4-Deoxypyridoxine 5'-phosphate

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PRODUCTS SPECIFICATIONS [883-84-1]

Catalog

HY-N2553

Brand

MCE

CAS

883-84-1

DESCRIPTION [883-84-1]

Overview

MDL	-
Molecular Weight	233.16
Molecular Formula	C8H12NO5P
SMILES	CC1=C(C(C)=NC=C1COP(O)(O)=O)O

For research use only. We do not sell to patients.

Summary

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a K _i of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate ( K _i of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase ^[1] ^[2] ^[3] .

IC50 & Target

Sphingosine 1-phosphate (S1P) ^[1]
Ornithine decarboxylase ^[2]
Glutamate apodecarboxylase ^[3]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 428.89 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2889 mL	21.4445 mL	42.8890 mL
5 mM	0.8578 mL	4.2889 mL	8.5778 mL
10 mM	0.4289 mL	2.1445 mL	4.2889 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.72 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.72 mM); Clear solution

* All of the co-solvents are available by MCE.