[CAS NO. 886-38-4] Diphenylcyclopropenone

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PRODUCTS SPECIFICATIONS [886-38-4]

Catalog

HY-W014605

Brand

MCE

CAS

886-38-4

DESCRIPTION [886-38-4]

Overview

MDL	MFCD00001311
Molecular Weight	206.24
Molecular Formula	C15H10O
SMILES	O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3

For research use only. We do not sell to patients.

Summary

Diphenylcyclopropenone (Diphencyprone) is a topical immunomodulatory agent that can be used for alopecia areata research ^[1] ^[2] .

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04775979	Ain Shams University	Vitiligo	January 17, 2021	Phase 4
NCT05020496	University of Alabama at Birmingham	Skin Diseases	March 21, 2022	Early Phase 1
NCT01452594	Rockefeller University	Healthy Volunteers	October 2011
NCT03651752	University of Minnesota\|National Alopecia Areata Foundation	Alopecia Areata	November 1, 2019	Phase 3
NCT01978483	Innovaderm Research Inc.	Ultraviolet Rays\|Immunosuppression\|Hypersensitivity, Delayed\|Immune Tolerance+Drug Effects	November 2013	Phase 1
NCT01711684	Rockefeller University	Neoplasm Metastasis\|Melanoma	October 16, 2012	Phase 1
NCT05481658	Nicholas Gulati\|Icahn School of Medicine at Mount Sinai	Cutaneous Metastases	September 2022	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 484.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8487 mL	24.2436 mL	48.4872 mL
5 mM	0.9697 mL	4.8487 mL	9.6974 mL
10 mM	0.4849 mL	2.4244 mL	4.8487 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2-Cyclopropen-1-one, 2,3-diphenyl-

Cyclopropenone, diphenyl-

2,3-Diphenyl-2-cyclopropen-1-one

2,3-Diphenylcyclopropenone

Diphenylcyclopropenone

1,2-Diphenylcyclopropenone

Diphencyprone

DPC

NSC 57541

Diphencyclopropenone

Diphenyl cyclopropenone

2,3-Diphenylcycloprop-2-enone

2,3-Diphenyl-cycloprop-2-enone