[CAS NO. 894787-30-5] ST2825

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PRODUCTS SPECIFICATIONS [894787-30-5]

Catalog

HY-50937

Brand

MCE

CAS

894787-30-5

DESCRIPTION [894787-30-5]

Overview

MDL	MFCD30207830
Molecular Weight	591.51
Molecular Formula	C27H28Cl2N4O5S
SMILES	O=C(N([C@H]1C(N)=O)[C@@](SCC1)([H])C2)[C@]2(CCC3)N3C(CC4=CC=C(C=C4)NC(COC(C(Cl)=C5)=CC=C5Cl)=O)=O

For research use only. We do not sell to patients.

58 Publications Citing Use of MCE

Summary

ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88 , causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity ^[1] ^[2] .

IC50 & Target

MyD88 ^[1]

In Vitro

ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization. ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at 5 μM ST2825 and 80% inhibition at 10 μM ST2825 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200 mg/kg, 5 min prior to i.p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 169.06 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6906 mL	8.4529 mL	16.9059 mL
5 mM	0.3381 mL	1.6906 mL	3.3812 mL
10 mM	0.1691 mL	0.8453 mL	1.6906 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution

* All of the co-solvents are available by MCE.