[CAS NO. 899759-16-1] MLKL-IN-2

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PRODUCTS SPECIFICATIONS [899759-16-1]

Catalog

HY-141889

Brand

MCE

CAS

899759-16-1

MDL	-
Molecular Weight	423.51
Molecular Formula	C26H25N5O
SMILES	O=C(C1=CC=C2C=CC=CC2=C1)NC3=CC=CC(C4=NN=C(N5CCN(C)CC5)C=C4)=C3

For research use only. We do not sell to patients.

MLKL-IN-2 is a MLKL inhibitor extracted from patent WO2021224505A1, compound (i) ^[1] .

MLKL ^[1]

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 10 mg/mL ( 23.61 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (2.36 mM); Clear solution

* All of the co-solvents are available by MCE.