[CAS NO. 90-50-6] 3,4,5-Trimethoxycinnamic acid

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PRODUCTS SPECIFICATIONS [90-50-6]

Catalog

HY-W012123

Brand

MCE

CAS

90-50-6

DESCRIPTION [90-50-6]

Overview

MDL	MFCD00004388
Molecular Weight	238.24
Molecular Formula	C12H14O5
SMILES	COC1=C(OC)C(OC)=CC(/C=C/C(O)=O)=C1

For research use only. We do not sell to patients.

Summary

3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals ^[1] ^[2] . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor , but shows no effect on the amounts of α-, β-subunits ^[2] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats ^[1] .
3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 419.74 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1974 mL	20.9872 mL	41.9745 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-

Cinnamic acid, 3,4,5-trimethoxy-

3-(3,4,5-Trimethoxyphenyl)-2-propenoic acid

3,4,5-Trimethoxycinnamic acid

O-Methylsinapic acid

3,4,5-Trimethoxyphenylacrylic acid

3-(3,4,5-Trimethoxyphenyl)propenoic acid

NSC 66175

3-(3,4,5-Trimethoxyphenyl)acrylic acid