[CAS NO. 9026-93-1] Adenosinedeaminase,microorganism
PRODUCTS SPECIFICATIONS [9026-93-1]
DESCRIPTION [9026-93-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | - |
| Molecular Formula | Unspecified |
| SMILES | [Adenosine deaminase] |
Summary
Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively.
In Vitro
Adenosine deaminase (ADA; EC 3.5.4.4) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells [1] . Adenosine deaminase is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT05300360 | TRPHARM |
Pulmonary Alveolar Proteinosis
|
August 16, 2021 | |
| NCT05300347 | TRPHARM |
Bronchiectasis|Adenosine Deaminase Deficiency|Pulmonary Disease
|
June 17, 2021 | |
| NCT05300334 | TRPHARM |
Adenosine Deaminase Deficiency
|
October 10, 2019 | |
| NCT04049084 | University of California, Los Angeles|Great Ormond Street Hospital for Children NHS Foundation Trust |
Adenosine Deaminase Deficiency|Severe Combined Immunodeficiency (SCID)
|
September 26, 2019 | |
| NCT05300373 | TRPHARM |
Adenosine Deaminase Deficiency
|
December 3, 2021 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234.
- [2] Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823.
Synonyms