[CAS NO. 903895-98-7] FPRAgonist43

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PRODUCTS SPECIFICATIONS [903895-98-7]

Catalog

HY-19574

Brand

MCE

CAS

903895-98-7

DESCRIPTION [903895-98-7]

Overview

MDL	MFCD30182236
Molecular Weight	384.86
Molecular Formula	C20H21ClN4O2
SMILES	O=C(NC1=C(C(C)C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(Cl)C=C3

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist ^[1] ^[2] .

IC50 & Target

FPR1, FPR2/ALX ^[1]

In Vitro

FPR Agonist 43 (10 ^-5 -10 ⁷ nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells ^[1] .
FPR Agonist 43 is also active in the GTPγ binding assay (IC ₅₀ =207±51 nM) ^[1] .
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors
Concentration:	10 ^-5 , 10 ^-3 , 0.1, 10, 1000, 10 ⁵ , 10 ⁷ nM
Incubation Time:
Result:	Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC ₅₀ =11.6±1.9 nM).

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 37.5 mg/mL ( 97.44 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5983 mL	12.9917 mL	25.9835 mL
5 mM	0.5197 mL	2.5983 mL	5.1967 mL
10 mM	0.2598 mL	1.2992 mL	2.5983 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.40 mM); Clear solution

* All of the co-solvents are available by MCE.