[CAS NO. 905973-89-9] CGK733

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PRODUCTS SPECIFICATIONS [905973-89-9]

Catalog

HY-15520

Brand

MCE

CAS

905973-89-9

DESCRIPTION [905973-89-9]

Overview

MDL	MFCD09038682
Molecular Weight	555.84
Molecular Formula	C23H18Cl3FN4O3S
SMILES	FC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=S)C=C1[N+]([O-])=O

For research use only. We do not sell to patients.

4 Publications Citing Use of MCE

Summary

CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer .

IC50 & Target

ATM

ATR

In Vitro

CGK733 (4.2 ng/μL-12.5 ng/μL) enhances taxol-induced cytotoxicity in HBV-positive HCC cells. CGK733 (4.2 ng/μL) accelerates the formation of multinucleated cells and promotes the exit of mitosis in taxol-treated HBV-positive HCC cells ^[1] . CGK733 (10 μM) causes the loss of cyclin D1 through the ubiquitin-dependent proteasomal degradation pathway in MCF-7 and T47D breast cancer cell lines. CGK733 (0.6-40 μM) shows inhibitory activities against proliferation of LnCap prostate cancer cells, HCT116 colon cancer cells, MCF-7 and T47D estrogen receptor positive breast cancer cells, and MDA-MB436 ER negative breast cancer cells. Moreover, CGK733 inhibits proliferation of non-transformed mouse BALB/c 3T3 embryonic fibroblast cells. In addition, CGK733 (10 μM) inhibits MCF-7 proliferation, and the effect can not be suppressed by pan-caspase inhibition ^[2] . CGK733 (10 μM) results in 1.6-fold increase in ATM reporter activity in HEK-293 cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGK733 (25 mg/kg, i.p.) increases the ATM reporter activity (reports inactivation of ATM kinase activity) compared to control mice, with 2.4-fold, 3.1-fold, and 1.3-fold changes at 1, 4, and 8 hours, respectively ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 179.91 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7991 mL	8.9954 mL	17.9908 mL
5 mM	0.3598 mL	1.7991 mL	3.5982 mL
10 mM	0.1799 mL	0.8995 mL	1.7991 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.74 mM); Clear solution

* All of the co-solvents are available by MCE.