[CAS NO. 909664-41-1] BPU-11
PRODUCTS SPECIFICATIONS [909664-41-1]
DESCRIPTION [909664-41-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 501.62 |
| Molecular Formula | C32H31N5O |
| SMILES | O=C(N(CC1=CC=CN=C1)C2CCN(CC2)CC3=CC=CC(C#N)=C3)NC4=CC=CC=C4C5=CC=CC=C5 |
Summary
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease [1] .
In Vitro
BPU-11 (100 μM) abolishes the HCN4 cAMP-induced shift in V
1/2
with a k
1/2
of 0.42 μM
[1]
.
BPU (100 and 200 μM) is specific of the HCN4 isoform and shows no effect on human HCN2 channels expressed in HEK293T cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 125 mg/mL ( 249.19 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9935 mL | 9.9677 mL | 19.9354 mL |
| 5 mM | 0.3987 mL | 1.9935 mL | 3.9871 mL |
| 10 mM | 0.1994 mL | 0.9968 mL | 1.9935 mL |