[CAS NO. 915363-56-3] Cotinhibitor-2
PRODUCTS SPECIFICATIONS [915363-56-3]
DESCRIPTION [915363-56-3]
Overview
| MDL | MFCD13184702 |
|---|---|
| Molecular Weight | 539.43 |
| Molecular Formula | C26H25Cl2FN8 |
| SMILES | N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5 |
2 Publications Citing Use of MCE
Summary
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC 50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC 50 of 0.3 μM [1] .
IC50 & Target
COT/Tpl2 [1]
In Vivo
Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a C max of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83% [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 40 mg/mL ( 74.15 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8538 mL | 9.2690 mL | 18.5381 mL |
| 5 mM | 0.3708 mL | 1.8538 mL | 3.7076 mL |
| 10 mM | 0.1854 mL | 0.9269 mL | 1.8538 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 3 mg/mL (5.56 mM); Clear solution
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