[CAS NO. 92-43-3] Phenidone
PRODUCTS SPECIFICATIONS [92-43-3]
DESCRIPTION [92-43-3]
Overview
| MDL | MFCD00003094 |
|---|---|
| Molecular Weight | 162.19 |
| Molecular Formula | C9H10N2O |
| SMILES | O=C1NN(C2=CC=CC=C2)CC1 |
Summary
Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX) , ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat [1] [2] . Phenidone is used as a photographic developer [3] .
IC50 & Target
|
COX |
LOX |
In Vitro
Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL ( 616.56 mM ; Need ultrasonic)
H 2 O : 3.33 mg/mL ( 20.53 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.1656 mL | 30.8280 mL | 61.6561 mL |
| 5 mM | 1.2331 mL | 6.1656 mL | 12.3312 mL |
| 10 mM | 0.6166 mL | 3.0828 mL | 6.1656 mL |
References
- [1] Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210.
- [2] Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58.
- [3] Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.
Synonyms