[CAS NO. 921605-87-0] MF-438
PRODUCTS SPECIFICATIONS [921605-87-0]
DESCRIPTION [921605-87-0]
Overview
| MDL | MFCD28386313 |
|---|---|
| Molecular Weight | 421.44 |
| Molecular Formula | C19H18F3N5OS |
| SMILES | FC(C1=CC=CC=C1OC2CCN(C3=NN=C(C4=NN=C(C)S4)C=C3)CC2)(F)F |
1 Publications Citing Use of MCE
Summary
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC 50 of 2.3 nM for rSCD1 [1] .
IC50 & Target
EC 50 : 2.3 nM (rSCD1) [1]
In Vivo
MF-438 exhibits an ED 50 between 1 and 3 mg/kg in a mouse model [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMF : 50 mg/mL ( 118.64 mM ; Need ultrasonic)
DMSO : 25 mg/mL ( 59.32 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3728 mL | 11.8641 mL | 23.7282 mL |
| 5 mM | 0.4746 mL | 2.3728 mL | 4.7456 mL |
| 10 mM | 0.2373 mL | 1.1864 mL | 2.3728 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMF >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution
-
3.
-
4.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution
-
5.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution