[CAS NO. 923562-23-6] FLT3-IN-2
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PRODUCTS SPECIFICATIONS [923562-23-6]
Catalog
HY-18744
Brand
MCE
CAS
923562-23-6
DESCRIPTION [923562-23-6]
Overview
| MDL | MFCD29472260 |
|---|---|
| Molecular Weight | 416.83 |
| Molecular Formula | C21H16ClF3N4 |
| SMILES | FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=C1)(F)F |
For research use only. We do not sell to patients.
Summary
FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
In Vitro:
DMSO : ≥ 30 mg/mL ( 71.97 mM )
* "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3991 mL | 11.9953 mL | 23.9906 mL |
| 5 mM | 0.4798 mL | 2.3991 mL | 4.7981 mL |
| 10 mM | 0.2399 mL | 1.1995 mL | 2.3991 mL |
*
Please refer to the solubility information to select the appropriate solvent.
References
- [1] Zhang, Chao, et al. Kinase modulation for the treatment of leukemias. From PCT Int. Appl. (2012), WO 2012158957 A2 20121122.
- [2] Zhang Chao, et al. 7-Azaindole derivatives and their preparation, pharmaceutical compositions and use for modulating c-kit and c-fms activity. From PCT Int. Appl. (2007), WO 2007013896 A2 20070201.
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