[CAS NO. 924296-39-9] HBX 41108
PRODUCTS SPECIFICATIONS [924296-39-9]
DESCRIPTION [924296-39-9]
Overview
| MDL | MFCD16251537 |
|---|---|
| Molecular Weight | 266.64 |
| Molecular Formula | C13H3ClN4O |
| SMILES | N#CC1=C(C#N)N=C2C(C(C3=C2C=CC(Cl)=C3)=O)=N1 |
Summary
HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC 50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines [1] [2] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 250 mg/mL ( 937.59 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7504 mL | 18.7519 mL | 37.5037 mL |
| 5 mM | 0.7501 mL | 3.7504 mL | 7.5007 mL |
| 10 mM | 0.3750 mL | 1.8752 mL | 3.7504 mL |
References
- [1] Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.
- [2] Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.