[CAS NO. 924416-43-3] AdipoRon

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PRODUCTS SPECIFICATIONS [924416-43-3]

Catalog

HY-15848

Brand

MCE

CAS

924416-43-3

DESCRIPTION [924416-43-3]

Overview

MDL	MFCD08271060
Molecular Weight	428.52
Molecular Formula	C27H28N2O3
SMILES	O=C(NC1CCN(CC2=CC=CC=C2)CC1)COC3=CC=C(C(C4=CC=CC=C4)=O)C=C3

For research use only. We do not sell to patients.

15 Publications Citing Use of MCE

Summary

AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K _d s of 1.8 and 3.1 μM, respectively.

IC50 & Target

Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2) ^[1]

In Vitro

AdipoRon is an orally active and specific AdipoR agonist, binds to AdipoR1 and AdipoR2, with K _d s of 1.8 and 3.1 μM. AdipoRon (50 nM-50 μM) increases AMPK phosphorylation via AdipoR1 ^[1] . AdipoRon (50 μM) dose-dependently attenuates the expression of TNF-α and TGF-β1 in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages ^[2] . AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis ^[3] . AdipoRon exerts vasodilation by mechanisms distinct to adiponectin and induces vasorelaxation without a marked decrease in VSMC [Ca ²⁺ ] _i ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AdipoRon (50 mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1 ^−/− Adipor2 ^−/− double-knockout mice ^[1] . AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg) ^[2] . Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 44 mg/mL ( 102.68 mM )

H ₂ O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3336 mL	11.6681 mL	23.3361 mL
5 mM	0.4667 mL	2.3336 mL	4.6672 mL
10 mM	0.2334 mL	1.1668 mL	2.3336 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.85 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.85 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.85 mM); Clear solution

* All of the co-solvents are available by MCE.