[CAS NO. 933054-33-2] Monomethyl lithospermate
PRODUCTS SPECIFICATIONS [933054-33-2]
DESCRIPTION [933054-33-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 552.48 |
| Molecular Formula | C28H24O12 |
| SMILES | O=C(/C=C/C1=C2C(O[C@@H]([C@H]2C(OC)=O)C3=CC(O)=C(O)C=C3)=C(O)C=C1)O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O |
Summary
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis . Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) [1] .
In Vitro
Monomethyl lithospermate (5, 10, and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated by oxygen and glucose deprivation/Reoxygenation (OGD/R)
[1]
.
Monomethyl lithospermate (20 μM; 12 h) alleviates cell damage, mitochondrial membrane potential loss and apoptosis of SHSY-5Y cells after oxygen and glucose deprivation/reoxygenation
[1]
.
Monomethyl lithospermate (5, 10, and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells
[1]
.
Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Immunofluorescence [1]
| Cell Line: | SHSY-5Y cells |
| Concentration: | 5, 10, and 20 μM |
| Incubation Time: | 12 hours |
| Result: | Inhibited the mitochondrial membrane potential (MMOP) collapse and apoptosis of SHSY-5Y cells induced by oxygen and glucose deprivation/Reoxygenation (OGD/R) treatment. |
In Vivo
Monomethyl lithospermate (72.4 μM/kg; p.o.; once daily for 14 d) improves the neurological function of middle artery occlusion (MCAO) rats 24 h after ischemia reperfusion (IR), and reduces the size of cerebral infarction; also reduces the level of oxidative stress and inhibit neuronal apoptosis in MCAO rats
[1]
.
Monomethyl lithospermate can reduce the oxidative stress level and inhibit neuronal apoptosis in MCAO rats
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.