[CAS NO. 93800-59-0] 8α,9α-Epoxycoleon-U-quinone
PRODUCTS SPECIFICATIONS [93800-59-0]
DESCRIPTION [93800-59-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 360.40 |
| Molecular Formula | C20H24O6 |
| SMILES | O=C([C@@]1(O[C@@]213)C(C(O)=C4[C@@]2(CCCC(C)4C)C)=O)C(C(C)C)=C(O)C3=O |
Summary
8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells ( SI=2.0 ). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX [1] .
In Vitro
8α,9α-Epoxycoleon-U-quinone (2, 5, 10, 20, 50 μM; 72 h) selective towards cancer cell lines, with a selectivity index of 2.0
[1]
.
8α,9α-Epoxycoleon-U-quinone (10 μM; 72 h) is able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells
[1]
.
8α,9α-Epoxycoleon-U-quinone (1, 2, 5 μM; 72 h) reverses the resistance of cancer cells to DOX and increase anti-cancer efficacy of DOX
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | NCI-H460, NCI-H460/R, MRC-5 cells |
| Concentration: | 2, 5, 10, 20, 50 μM |
| Incubation Time: | 72 h |
| Result: | Showed inhibition of cancer cell viability (IC 50 ≈20 μM) with a selectivity index of 2.0. |
Cell Viability Assay [1]
| Cell Line: | NCI-H460/R cells |
| Concentration: | 10 μM |
| Incubation Time: | 72 h |
| Result: | Decreased the Rho123 accumulation in NCI-H460/R cells, and no influence on the ABCB1 expression. |
Cell Viability Assay [1]
| Cell Line: | NCI-H460/R cells |
| Concentration: | 1, 2, 5 μM (combine with Doxorubicin (DOX)) |
| Incubation Time: | 72 h (pre-treat) |
| Result: | Promoted sensitization of NCI-H4l60/R cells to DOX with relative reversal indexes of 1.976 and 4.696 for concentration of 1 and 2 μM, respectively. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.