[CAS NO. 940310-85-0] NVP-BHG712

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PRODUCTS SPECIFICATIONS [940310-85-0]

Catalog

HY-13258A

Brand

MCE

CAS

940310-85-0

DESCRIPTION [940310-85-0]

Overview

MDL	MFCD20272929
Molecular Weight	503.48
Molecular Formula	C26H20F3N7O
SMILES	CC1=CC=C(C=C1NC2=NC(C3=CC=CN=C3)=NC4=C2C=NN4C)C(NC5=CC=CC(C(F)(F)F)=C5)=O

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC ₅₀ values of 3.3 nM and 3.0 nM for EphA2 and EphB4 , respectively ^[1] ^[2] .

IC50 & Target

IC50: 3.3 nM (EphA2), 3 nM (EphB4) ^[2] .

In Vitro

NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice arrying chambers ^[1] .
Dosage:	3, 10 and 30 mg/kg.
Administration:	P.O. daily for 4 days.
Result:	Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 31.25 mg/mL ( 62.07 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9862 mL	9.9309 mL	19.8618 mL
5 mM	0.3972 mL	1.9862 mL	3.9724 mL
10 mM	0.1986 mL	0.9931 mL	1.9862 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution

* All of the co-solvents are available by MCE.