[CAS NO. 94079-81-9] Poliumoside

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PRODUCTS SPECIFICATIONS [94079-81-9]

Catalog

HY-N0033

Brand

MCE

CAS

94079-81-9

DESCRIPTION [94079-81-9]

Overview

MDL	-
Molecular Weight	770.73
Molecular Formula	C35H46O19
SMILES	OC1=C(O)C=CC(CCOC2C(C(OC3OC(C)C(O)C(O)C3O)C(OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C(COC5OC(C)C(O)C(O)C5O)O2)O)=C1

For research use only. We do not sell to patients.

Summary

Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase ( RLAR ) inhibitor, with IC ₅₀ s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity ^[1] ^[2] ^[3] .

IC50 & Target

IC50: 8.47 μM (aldose reductase) ^[1]

In Vitro

Poliumoside inhibits AGE formation and RLAR, with IC ₅₀ s of 19.69, and 8.47 μM, respectively ^[1] .
Poliumoside (5-30 μM; 3 h) inhibits AAPH-induced hemolysis of rat red blood cells in vitro ^[2] .
Poliumoside (12.5-100 μM; pretreated 2 h) inhibits the release of TNF-α and IL-6 in LPS-induced RAW 264.7 cells ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Poliumoside inhibits vessel dilation in larval zebrafish ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 129.75 mM ; Need ultrasonic)

Ethanol : 50 mg/mL ( 64.87 mM ; Need ultrasonic)

H ₂ O : 50 mg/mL ( 64.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2975 mL	6.4874 mL	12.9747 mL
5 mM	0.2595 mL	1.2975 mL	2.5949 mL
10 mM	0.1297 mL	0.6487 mL	1.2975 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Poliumoside