[CAS NO. 943962-47-8] BMS-303141

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PRODUCTS SPECIFICATIONS [943962-47-8]

Catalog

HY-16107

Brand

MCE

CAS

943962-47-8

DESCRIPTION [943962-47-8]

Overview

MDL	MFCD25976797
Molecular Weight	424.30
Molecular Formula	C19H15Cl2NO4S
SMILES	O=S(C1=CC(Cl)=CC(Cl)=C1O)(NC2=CC(C3=CC=CC=C3)=CC=C2OC)=O

For research use only. We do not sell to patients.

8 Publications Citing Use of MCE

Summary

BMS-303141 is a potent, cell-permeable ATP-citrate lyase ( ACL ) inhibitor with an IC ₅₀ of 0.13 μM.

IC50 & Target

IC50: 0.13 uM (ACL) ^[1]

In Vitro

In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC ₅₀ of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 58.92 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3568 mL	11.7841 mL	23.5682 mL
5 mM	0.4714 mL	2.3568 mL	4.7136 mL
10 mM	0.2357 mL	1.1784 mL	2.3568 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.89 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.89 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (5.89 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Li JJ, et al. 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.