[CAS NO. 94596-28-8] Senkyunolide I

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PRODUCTS SPECIFICATIONS [94596-28-8]

Catalog

HY-N0745

Brand

MCE

CAS

94596-28-8

DESCRIPTION [94596-28-8]

Overview

MDL	-
Molecular Weight	224.25
Molecular Formula	C12H16O4
SMILES	O=C1O/C(C2=C1[C@H](O)[C@@H](O)CC2)=C\CCC

For research use only. We do not sell to patients.

Summary

Senkyunolide I, isolated from Ligusticum chuanxiong Hort, is an anti-migraine compound. Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3 ^[1] ^[2] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 445.93 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4593 mL	22.2965 mL	44.5931 mL
5 mM	0.8919 mL	4.4593 mL	8.9186 mL
10 mM	0.4459 mL	2.2297 mL	4.4593 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1(3H)-Isobenzofuranone, 3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6R,7R)-rel-

1(3H)-Isobenzofuranone, 3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6α,7β)-

rel-(3Z,6R,7R)-3-Butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone

Senkyunolide I