[CAS NO. 947699-46-9] ZIKV-IN-3
PRODUCTS SPECIFICATIONS [947699-46-9]
DESCRIPTION [947699-46-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 587.75 |
| Molecular Formula | C39H41NO4 |
| SMILES | O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[C@@]23C)=N/O)=C |
Summary
IC50 & Target
IC50: 18.34 μM (MTase) [1]
In Vitro
ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC
50
value of 0.76 μM and has anti-ZIKV effect with EC
50
values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively
[1]
.
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC
50
value of 0.38 μM and inhibits ZIKV replication and infection
[1]
.
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells
[1]
.
Vero, Huh7 and A549 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Vero, Huh7 and A549 cells |
| Concentration: | 0.08, 0.4, 2, 10, and 50 μM |
| Incubation Time: | 96 hours |
| Result: | Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC 50 >200 μM to all three cell lines. |
Western Blot Analysis [1]
| Cell Line: | Vero cells |
| Concentration: | 0.08, 0.4, 2, 10, and 50 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the expression of ZIKV E protein in a dose-dependent manner. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.