[CAS NO. 95510-70-6] Omeprazolesodium

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PRODUCTS SPECIFICATIONS [95510-70-6]

Catalog

HY-B0113A

Brand

MCE

CAS

95510-70-6

DESCRIPTION [95510-70-6]

Overview

MDL	MFCD07802816
Molecular Weight	367.40
Molecular Formula	C17H18N3NaO3S
SMILES	O=S(C1=NC2=CC=C(OC)C=C2N1[Na])CC3=NC=C(C)C(OC)=C3C

For research use only. We do not sell to patients.

Summary

Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a K _i of 2 to 6 μM ^[1] . Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria ^[2] . Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) ^[3] .

In Vitro

Omeprazole (H 16868) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger-Ellison syndrome. Omeprazole (H 16868) virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001). This inhibition of 24 hour intragastric acidity is more profound than that previously reported with either cimetidine 1 g daily or ranitidine 300 mg daily ^[1] . The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of Omeprazole (H 16868) from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole (H 16868) increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound ^[2] .
Omeprazole sodium is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02584751	James J. Peters Veterans Affairs Medical Center	Gastro Esophageal Reflux Disorder	August 2016	Phase 1
NCT00256737	AstraZeneca	GERD	January 1998	Phase 3
NCT00818870	Vecta Ltd.	Gastroesophageal Reflux	December 2008	Phase 1
NCT02684799	Tobira Therapeutics, Inc.	Healthy	January 31, 2016	Phase 1
NCT00210470	Brooklyn ImmunoTherapeutics, LLC	Squamous Cell Carcinoma of the Head and Neck	July 2005	Phase 2
NCT02253875	Boehringer Ingelheim	Healthy	November 2005	Phase 1
NCT04901663	Dow University of Health Sciences	Helicobacter Pylori Infection	June 21, 2021	Phase 4
NCT02220777	Astellas Pharma Europe B.V.\|Astellas Pharma Inc	Pharmacokinetics of ASP8477\|Pharmacodynamics of ASP8477	November 2010	Phase 1
NCT02190708	Vivoryon Therapeutics N.V.\|Covance	Healthy Volunteers\|Pharmacologic Action	June 2014	Phase 1
NCT00164931	Chinese University of Hong Kong	Peptic Ulcer Hemorrhage	October 2003	Phase 3
NCT00002682	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Lymphoma	August 10, 1995	Phase 2
NCT03146325	The University of Texas Health Science Center, Houston\|Baylor College of Medicine	Helicobacter Pylori Infection	November 2012	Phase 4
NCT03781596	Claire Daniels\|Walter Reed National Military Medical Center	Eosinophilic Esophagitis	October 2, 2018	Phase 4
NCT01287195	Brigham and Women´s Hospital	Ulcerative Colitis	April 7, 2011	Phase 1\|Phase 2
NCT02685150	Chinese PLA General Hospital	Gastroesophageal Reflux Disease\|Dyspepsia\|Bile Reflux	January 2016	Not Applicable
NCT02986334	Apkar Apkarian\|National Center for Complementary and Integrative Health (NCCIH)\|National Institutes of Health (NIH)\|Northwestern University	Chronic Low Back Pain	August 2016	Phase 4
NCT03205228	Mahidol University	Globus	July 7, 2017	Phase 3
NCT01287598	Bayer	Neoplasms	August 2, 2011	Phase 1
NCT02229877	Afferent Pharmaceuticals, Inc.\|Celerion	Healthy Volunteers	October 6, 2014	Phase 1
NCT02623816	MetroHealth Medical Center	Heartburn	August 2014	Phase 4
NCT02893709	Changi General Hospital\|National University, Singapore\|Universiti Teknologi Mara	Gastroesophageal Reflux Disease	June 2015	Not Applicable
NCT01150162	Otsuka Pakistan Limited	Gastric Ulcer	October 2010	Phase 3
NCT00404534	Hospital de Clinicas de Porto Alegre\|Aché Laboratórios Farmacêuticos Ltda	Functional Dyspepsia	October 2006	Phase 3
NCT03165253	Bulent Ecevit University	Helicobacter Pylori Infection	June 2011	Not Applicable
NCT03980496	Medical University of Bialystok\|National Science Centre, Poland	Non-variceal Upper Gastrointestinal Bleeding	September 9, 2010	Phase 4
NCT00641264	AstraZeneca	Laryngopharyngeal Reflux (LPR)	May 2001	Phase 4
NCT04425902	ViiV Healthcare	HIV Infections	December 16, 2020	Phase 1
NCT02790840	Afferent Pharmaceuticals, Inc.	Healthy	May 16, 2016	Phase 1
NCT03131973	Bristol-Myers Squibb	Rheumatoid Arthritis	May 13, 2017	Phase 1
NCT01218620	National Cancer Institute (NCI)	Adult Solid Neoplasm	September 2010	Phase 1
NCT02730026	Luis Fernando Simoneti\|Fundação de Amparo à Pesquisa do Estado de São Paulo\|University of Sao Paulo	Pain\|Other Surgical Procedures	June 2015	Phase 4
NCT02595372	Kathy Miller\|Indiana University	Cancer of the Breast	November 12, 2015	Phase 2
NCT01335334	The University of Texas Health Science Center, Houston	H. Pylori Infection	March 2011	Phase 4
NCT05609929	AnHeart Therapeutics Inc.	Pharmacokinetic Study	November 2, 2022	Phase 1
NCT01921920	AstraZeneca	Bioequivalence, AUC, Cmax, Pharmacokinetics	August 2013	Phase 1
NCT00772837	Aga Khan University	Functional Dyspepsia\|Helicobacter Pylori Infection	August 2006	Not Applicable
NCT02524210	Centre Hospitalier Universitaire de Saint Etienne	Healthy	May 2014	Phase 1
NCT01462318	Biogen	Relapsing-Remitting Multiple Sclerosis	November 2011	Phase 3
NCT01170533	University of Florida\|Bristol-Myers Squibb\|Sanofi	Drug Interaction	March 2009	Phase 1
NCT01470690	Radboud University Medical Center\|Merck Sharp & Dohme LLC	HCV Infections\|Gastric Acid-related Disorders	October 2011	Phase 1
NCT04149470	University of Colorado, Denver\|Children´s Hospital Colorado	Eosinophilic Esophagitis	October 7, 2020	Phase 4
NCT02013427	Northwestern University\|National Center for Complementary and Integrative Health (NCCIH)\|National Institutes of Health (NIH)	Chronic Low Back Pain	October 2014	Phase 4
NCT00582972	University of Wisconsin, Madison	Osteoporosis\|Achlorhydria\|GERD\|Hip Fracture	January 2008	Phase 4
NCT02013453	University of Michigan Rogel Cancer Center	Cancer of Head and Neck	December 2013	Phase 2
NCT02153177	University of Chicago	Rotator Cuff Tear	January 2015	Phase 4
NCT00519519	Singapore General Hospital	Bleeding Peptic Ulcers Disease	July 2004	Phase 3
NCT00559182	Merck Sharp & Dohme LLC	Advanced Cancer	December 5, 2007	Phase 1
NCT00930306	AstraZeneca	Chronic Pain	June 2009	Phase 1
NCT03551691	Children´s Hospital of Philadelphia\|Chiesi USA, Inc.	Pancreatic Insufficiency\|Cystic Fibrosis	August 7, 2018	Phase 2
NCT04333407	Imperial College London	COVID-19	April 3, 2020	Not Applicable
NCT04108676	Jiangsu HengRui Medicine Co., Ltd.\|The Third Xiangya Hospital of Central South University	Advanced Solid Tumor	September 7, 2019	Phase 1
NCT04643249	Abliva AB	Mitochondrial Disease	November 10, 2020	Phase 1
NCT04718181	Hoffmann-La Roche	Muscular Atrophy, Spinal	February 1, 2021	Phase 1
NCT02473627	Daiichi Sankyo, Inc.	Healthy	May 2015	Phase 1
NCT00633932	AstraZeneca	Reflux Esophagitis	December 2007	Phase 3
NCT03530995	Kadmon Corporation, LLC\|Quotient Sciences	Drug-drug Interaction\|Autoimmune Diseases\|Fibrotic Disease	April 9, 2018	Phase 1
NCT02638116	Janssen Research & Development, LLC	Healthy	January 2016	Phase 1
NCT05319912	Alexion Pharmaceuticals	Healthy	April 7, 2014	Phase 1
NCT00655746	Bristol-Myers Squibb	Healthy	April 2008	Phase 1
NCT03358706	Janssen Research & Development, LLC	Crohn Disease\|Ulcerative Colitis	February 2, 2018	Phase 1
NCT03363815	Celgene	Heathy Volunteer	December 4, 2017	Phase 1
NCT01452906	Vifor Pharma	Healthy	September 2011	Phase 1
NCT00259051	AstraZeneca\|Mitsubishi Tanabe Pharma Corporation	Non-erosive Reflux Disease	January 2004	Phase 3
NCT03362268	Livzon Pharmaceutical Group Inc.	Peptic Ulcer Hemorrhage	February 2014	Phase 2
NCT03302845	Lexicon Pharmaceuticals	Drug-drug Interaction	September 21, 2017	Phase 1
NCT00964106	GlaxoSmithKline	Drug Interactions	August 26, 2009	Phase 1
NCT05134350	Loxo Oncology, Inc.\|Eli Lilly and Company	Healthy Volunteers	February 6, 2020	Phase 1
NCT03716427	Cognition Therapeutics	Healthy Volunteers	November 10, 2016	Phase 1
NCT04525664	Washington University School of Medicine	Helicobacter Pylori Infection\|Dyspepsia	October 1, 2018	Early Phase 1
NCT00141102	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Osteoarthritis\|Arthritis, Rheumatoid	October 2005	Phase 4
NCT02472600	Stephen Harbarth\|European Commission\|University Hospital, Geneva	Intestinal Colonization With Multidrug-resistant Bacteria	February 2016	Phase 2
NCT03367195	Dexa Medica Group	Gastroesophageal Reflux Disease (GERD)	August 16, 2018	Phase 3
NCT00537732	Matthias Schwab\|Robert Bosch Gesellschaft für Medizinische Forschung mbH	Gastroesophageal Reflux	April 2007	Phase 4
NCT01795794	Soroka University Medical Center	CDA Type I	April 2013	Phase 4
NCT00045799	Bausch Health Americas, Inc.	Upper Gastrointestinal Bleeding	May 2002	Phase 3
NCT04876807	Acerta Pharma BV	Healthy Volunteers	January 28, 2016	Phase 1
NCT00247130	Keio University	Peptic Ulcers	October 2005	Phase 4
NCT01129375	Sanofi\|Bristol-Myers Squibb	Healthy	February 2009	Phase 1
NCT03864042	Pfizer\|Pierre Fabre Laboratories	Advanced Solid Tumors\|Metastatic Melanoma	January 2, 2018	Phase 1
NCT01489943	GlaxoSmithKline	Crohn´s Disease	September 19, 2011	Phase 1
NCT05599828	Amgen	Healthy Participants	July 17, 2020	Phase 1
NCT03662269	The First Affiliated Hospital of Guangzhou Medical University	Refractory Chronic Cough	October 22, 2018	Phase 3
NCT03908619	Changi General Hospital	Helicobacter Pylori Infection	April 16, 2019	Phase 4
NCT02123498	Loma Linda University	Eustachian Tube Dysfunction\|Laryngopharyngeal Reflux		Phase 4
NCT01593592	Zagazig University\|BioGaia AB	Helicobacter Pylori Infection	June 2012	Not Applicable
NCT01129388	Sanofi\|Bristol-Myers Squibb	Healthy	March 2009	Phase 1
NCT00952978	Livzon Pharmaceutical Group Inc.	Duodenal Ulcer	September 2005	Phase 3
NCT03936374	Bristol-Myers Squibb	Healthy	May 8, 2019	Phase 1
NCT01596647	Novartis Pharmaceuticals\|Novartis	Advanced Solid Tumors, Excluding Breast Cancer	May 2012	Phase 1
NCT05264142	University Hospital, Geneva	Healthy	April 1, 2022	Phase 1
NCT04959266	AstraZeneca\|Parexel	Advanced Solid Tumours	June 28, 2021	Phase 1
NCT00259077	AstraZeneca\|Mitsubishi Tanabe Pharma Corporation	Non-erosive Reflux Disease	October 2003	Phase 3
NCT01786382	Presidio Pharmaceuticals, Inc.	Pharmacokinetic Assessments in Healthy Volunteers	February 2013	Phase 1
NCT05067439	Pfizer	Healthy Participants	October 21, 2021	Phase 1
NCT03033342	MicuRx\|Worldwide Clinical Trials	Safety	August 2, 2016	Phase 1
NCT01129414	Sanofi\|Bristol-Myers Squibb	Healthy	June 2009	Phase 1
NCT02609386	Brooklyn ImmunoTherapeutics, LLC	Squamous Cell Carcinoma of the Oral Cavity	December 2015	Phase 2
NCT02365558	Eli Lilly and Company	Healthy	January 2015	Phase 1
NCT04198948	University of Sarajevo\|General Hospital Prim. Dr. Abdulah Nakas\|University of Dundee\|Wellcome Trust	Diabetes Mellitus, Type 2	March 4, 2019	Phase 1
NCT03793556	SOFAR S.p.A.	Gastro-oesophageal Reflux Disease	May 5, 2017	Not Applicable
NCT00838682	The Catholic University of Korea\|Janssen Korea, Ltd., Korea	Peptic Ulcer Hemorrhage	April 2006	Phase 4
NCT04199624	Indiana University\|Hala Fadda\|Butler University	Hypochlorhydria	October 1, 2021	Phase 1
NCT00674115	Bayer\|Bausch Health Americas, Inc.	Gastric Acid\|Human Experimentation	April 2008	Phase 3
NCT01678053	Phillip Song, MD\|Massachusetts Eye and Ear Infirmary	Contact Ulcer of Vocal Folds\|Granuloma of Vocal Cords\|Granuloma, Laryngeal\|Granuloma	September 2012	Phase 2
NCT01782560	Children´s & Women´s Health Centre of British Columbia	Laryngomalacia	February 2013	Phase 1
NCT05468164	Eli Lilly and Company\|Loxo Oncology, Inc.	Healthy	May 31, 2018	Phase 1
NCT02724150	Damascus Hospital	Gastroduodenal Ulcer\|Marginal Ulcer\|Peptic Ulcer Hemorrhage	December 1, 2017	Phase 4
NCT03457727	GlaxoSmithKline	Pulmonary Disease, Chronic Obstructive	March 7, 2018	Phase 1
NCT02740712	Clovis Oncology, Inc.	Neoplasms	April 2016	Phase 1
NCT01000818	Merck Sharp & Dohme LLC	HIV-1 Infection\|HIV Infections	June 2008	Phase 1
NCT01539655	Sanofi	Medullary Thyroid Cancer	February 2012	Phase 1
NCT05487235	Genentech, Inc.	Advanced Solid Tumors\|Metastatic Solid Tumors	August 17, 2022	Phase 1
NCT02492776	Afferent Pharmaceuticals, Inc.\|Celerion	Healthy	July 7, 2015	Phase 1
NCT03362281	Livzon Pharmaceutical Group Inc.	Peptic Ulcer Hemorrhage	October 2014	Phase 3
NCT01045642	Dr. Reddy´s Laboratories Limited	Healthy	December 2006	Phase 1
NCT02407119	National Cancer Center, Korea	Helicobacter Pylori Infection\|Early Gastric Cancer\|Endoscopic Resection	June 2003	Phase 3
NCT00442741	Novartis Pharmaceuticals\|Novartis	Solid Tumors	July 2007	Phase 1
NCT01657578	Assistance Publique - Hôpitaux de Paris	Gastroesophageal Reflux Disease (GERD)	June 2007	Phase 2
NCT00942136	GlaxoSmithKline\|Shionogi	Healthy Volunteer	July 2009	Phase 1
NCT00854451	National Taiwan University Hospital\|National Science Council, Taiwan	Duodenal Ulcer\|Helicobacter Pylori Infection	August 1996	Phase 4
NCT01408849	Casa Espirita Terra de Ismael\|University of Sao Paulo	Dyspepsia	February 2015	Phase 2
NCT02345304	Boehringer Ingelheim	Healthy	March 2015	Phase 1
NCT02254148	Boehringer Ingelheim	Healthy	October 2014	Phase 1
NCT01983566	Boehringer Ingelheim	Healthy	November 2013	Phase 1
NCT00003617	Lymphoma Trials Office\|National Cancer Institute (NCI)	Gastric Cancer	March 1995	Phase 3
NCT02647086	Regeneron Pharmaceuticals\|Sanofi	Atopic Dermatitis	December 2015	Phase 1
NCT01000220	Shahid Beheshti University of Medical Sciences\|Ophthalmic Research Center	Glaucoma		Phase 1
NCT01694706	Boehringer Ingelheim	Healthy	September 2012	Phase 1
NCT03058419	Janssen Research & Development, LLC	Healthy	March 14, 2017	Phase 1
NCT02016820	Columbia University	Clostridium Difficile Infection	November 2014	Not Applicable
NCT03650543	Javeriana University\|Universidad Nacional de Colombia	CYP2C19 Polymorphism\|H.Pylori Infection\|Therapy	September 10, 2012	Phase 4
NCT01170182	Dr. Reddy´s Laboratories Limited	Healthy	February 2006	Phase 1
NCT03291249	Tiziana Life Sciences, PLC	NASH - Nonalcoholic Steatohepatitis\|NAFLD\|T2DM (Type 2 Diabetes Mellitus)	December 1, 2017	Phase 2
NCT00420615	Novartis Pharmaceuticals\|Novartis	Solid Tumors	December 2006	Phase 1
NCT04721704	Shaheed Zulfiqar Ali Bhutto Medical University	H Pylori Gastritis	September 14, 2020	Not Applicable
NCT03866434	Shire\|Takeda	Healthy Volunteers	February 26, 2019	Phase 1
NCT02922933	Syndax Pharmaceuticals	Volunteers\|Healthy Volunteers\|Human Volunteers\|Normal Volunteers	October 25, 2016	Phase 1
NCT01016717	Sheba Medical Center	Coronary Artery Disease	December 2012	Phase 4
NCT00442052	POZEN	Healthy	November 2006	Phase 1
NCT00251030	Pfizer\|Jasper Clinic, Michigan	Healthy Volunteers	November 2005	Phase 4
NCT01093755	Mayo Clinic	Inflammation\|Barrett´s Esophagus	March 2010	Phase 4
NCT02552537	University of Zurich\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|University of Nebraska Lincoln\|Region Hovedstadens Apotek\|University of Manchester\|Hospital San Carlos, Madrid	Food Allergy	September 2015	Phase 4
NCT02500641	Menarini International Operations Luxembourg SA	Gout	August 17, 2015	Phase 4
NCT01766050	Bristol-Myers Squibb	Transplant Rejection	January 2013	Phase 4
NCT03238534	Aboca Spa Societa´ Agricola\|Doppel Farmaceutici\|University of Roma La Sapienza\|BMR Genomics	GERD\|EPS	September 12, 2017	Phase 4
NCT03457597	Corcept Therapeutics	Healthy	March 6, 2018	Phase 1
NCT01813552	Merck Sharp & Dohme LLC	Chronic Hepatitis C Infection	February 2013	Phase 1
NCT04930991	University of Oklahoma	Exocrine Pancreatic Cancer	September 7, 2021	Early Phase 1
NCT03709355	Viriom	HIV-1-infection	November 14, 2018	Phase 1
NCT02256813	Boehringer Ingelheim	Healthy	September 2005	Phase 1
NCT00374101	Casa Sollievo della Sofferenza IRCCS	Peptic Ulcers\|Upper Gastrointestinal Bleeding	January 2005	Phase 3
NCT01094275	Neil Kleiman, MD\|The Methodist Hospital Research Institute	Coronary Artery Disease	January 2010
NCT01822977	Mayo Clinic	Healthy\|Clostridium Difficile Infection	March 2013	Phase 1
NCT02249871	Novo Nordisk A+S	Diabetes\|Healthy	September 24, 2014	Phase 1
NCT05319899	Alexion Pharmaceuticals	Healthy	January 20, 2014	Phase 1
NCT05338502	Eli Lilly and Company\|Loxo Oncology, Inc.	Healthy	July 8, 2019	Phase 1\|Phase 2
NCT01338077	Chang Gung Memorial Hospital	Gastroesophageal Reflux Disease\|Heartburn	October 2010	Phase 3
NCT01777854	Ascension Genesys Hospital	Laryngopharyngeal Reflux\|Throat Pain	January 2013	Phase 4
NCT02685436	Mansoura University Children Hospital	Gastroesophageal Reflux Disease	March 2013	Phase 4
NCT05444556	Eli Lilly and Company	Healthy	July 7, 2022	Phase 1
NCT02783040	Boehringer Ingelheim	Healthy	September 2015	Phase 1
NCT01170169	Dr. Reddy´s Laboratories Limited	Healthy	January 2006	Phase 1
NCT00640809	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Bowel Diseases, Inflammatory	October 2003	Phase 4
NCT00668317	Hull University Teaching Hospitals NHS Trust	Cough	September 2006	Phase 3
NCT05517928	Mayo Clinic	Healthy	January 2023	Not Applicable
NCT04128787	Agios Pharmaceuticals, Inc.	Healthy Volunteers	September 30, 2019	Phase 1
NCT00542347	Queen´s University\|Canadian Institutes of Health Research (CIHR)	Gastric Acid	September 2007	Phase 3
NCT01824199	Mayo Clinic	Esophagitis	March 2013	Early Phase 1
NCT03333824	AstraZeneca\|Quintiles, Inc.	Solid Tumours	December 1, 2017	Phase 1
NCT01499368	Boryung Pharmaceutical Co., Ltd	Erosive Esophagitis	November 2011	Phase 3
NCT02957474	Celgene	Healthy Volunteers	November 2016	Phase 1
NCT00446004	University of Pittsburgh\|Novartis	Healthy	April 2007	Phase 1
NCT00765206	Bayer\|Bausch Health Americas, Inc.	Gastric Acid\|Human Experimentation	May 2008	Phase 3
NCT02536989	Far Eastern Memorial Hospital	Peptic Ulcer\|Hemorrhage	March 2009	Phase 4
NCT01587885	Bayer	Heartburn	January 2012	Phase 4
NCT01636557	Janssen Research & Development, LLC	Arthritis, Rheumatoid	October 11, 2012	Phase 1
NCT02438072	University Hospital, Geneva	Depression	December 2014	Not Applicable
NCT00989300	Janssen Cilag S.A.S.	Healthy	November 2009	Phase 1
NCT04394663	King Chulalongkorn Memorial Hospital	GI Bleeding	October 1, 2020	Not Applicable
NCT00298779	Millennium Pharmaceuticals, Inc.\|Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Tumors\|Non-Hodgkins´s Lymphoma		Phase 1
NCT01711320	Xijing Hospital	Healthy	September 2012	Phase 1
NCT05581992	Amgen	Healthy Participants	January 6, 2020	Phase 1
NCT02621359	Tanta University	Dyspepsia	January 2015	Phase 3
NCT01925144	Eli Lilly and Company	Healthy Volunteers	October 2013	Phase 1
NCT04170270	Assiut University	Bleeding Peptic Ulcer	November 2019	Early Phase 1
NCT01415349	Shire\|Takeda	Healthy	August 11, 2011	Phase 1
NCT00953381	Livzon Pharmaceutical Group Inc.	Duodenal Ulcer	October 2004	Phase 2
NCT02772601	AbbVie\|Boehringer Ingelheim	Psoriasis	September 15, 2016	Phase 1
NCT03059303	Janssen Research & Development, LLC	Healthy	February 20, 2017	Phase 1
NCT00441519	POZEN	Healthy	February 2007	Phase 1
NCT05438303	AstraZeneca	Healthy Volunteers	June 13, 2022	Phase 1
NCT01465113	Case Comprehensive Cancer Center	Short Segment Barrett´s Esophagus\|Long Segment Barrett´s Esophagus	May 2010	Early Phase 1
NCT05497557	Amgen	Healthy Volunteers	August 4, 2022	Phase 1
NCT01566474	Aragon Institute of Health Sciences	Barrett´s Esophagus	April 2012	Phase 3
NCT01570569	Inje University	Healthy	January 2011	Phase 1
NCT01822600	National Cheng-Kung University Hospital\|National Science Council, Taiwan	Peptic Ulcer Bleeding\|Hypoalbuminemia	January 2010	Phase 4
NCT02085018	Newcastle-upon-Tyne Hospitals NHS Trust\|Newcastle University	Idiopathic Pulmonary Fibrosis	March 28, 2014	Phase 2
NCT00364481	West Side ENT	Obstructive Sleep Apnea\|Upper Airway Resistance Syndrome\|Gastroesophageal Reflux	August 2006	Phase 1
NCT01337804	Bayer	Heartburn	January 2011	Phase 1
NCT02433457	Celgene	Healthy Volunteers	May 26, 2014	Phase 1
NCT00861640	Kaohsiung Medical University Chung-Ho Memorial Hospital\|Kaohsiung Medical University	Nonvariceal Upper Gastrointestinal Bleeding	March 2009	Phase 4
NCT02518373	Cancer Advances Inc.	Colorectal Cancer	April 2000	Phase 2
NCT02397382	Janssen Research & Development, LLC	Psoriasis	June 18, 2015	Phase 1
NCT00164866	Chinese University of Hong Kong	Peptic Ulcer	February 2004	Phase 4
NCT05392127	Jiangsu HengRui Medicine Co., Ltd.	Rheumatoid Arthritis	July 15, 2022	Phase 1
NCT02555852	Canadian Network for Observational Drug Effect Studies, CNODES\|Drug Safety and Effectiveness Network, Canada\|Canadian Institutes of Health Research (CIHR)	Gastroesophageal Reflux Disease (GERD)\|Community-acquired Pneumonia	September 2011
NCT01147588	AstraZeneca	Healthy	May 2010	Phase 1
NCT01735227	Yaling Han\|Shenyang Northern Hospital	Acute Coronary Syndromes	November 2012	Phase 4
NCT01458990	Hunter Holmes Mcguire Veteran Affairs Medical Center	Cirrhosis\|Healthy	October 2011	Not Applicable
NCT01661101	Population Health Research Institute	Myocardial Injury After Noncardiac Surgery (MINS)	January 2013	Phase 3
NCT02394340	Bausch & Lomb Incorporated\|Bausch Health Americas, Inc.	Tinea Pedis\|Tinea Cruris	February 3, 2015	Phase 4
NCT00564590	Rabin Medical Center	Gastroesophageal Reflux Disease	October 2008	Phase 1\|Phase 2
NCT03163680	Damascus Hospital	Gastroduodenal Ulcer\|Marginal Ulcer\|Peptic Ulcer Hemorrhage	January 2012
NCT01392755	Hoffmann-La Roche	Healthy Volunteer	July 2011	Phase 1
NCT00559364	Forest Laboratories	Exocrine Pancreatic Insufficiency\|Chronic Pancreatitis\|Pancreatectomy	November 2007	Phase 3
NCT04337580	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Prostate Cancer\|Refractory Cancer\|Castration Resistant Prostatic Cancer	March 5, 2021	Phase 2
NCT03979989	Grünenthal GmbH\|Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Pharmacokinetic	September 28, 2005	Phase 1
NCT03267680	University of Southern California\|National Cancer Institute (NCI)\|Brooklyn ImmunoTherapeutics, LLC	Cervical Squamous Cell Carcinoma In Situ\|Vulvar High Grade Squamous Intraepithelial Lesion	November 8, 2017	Phase 2
NCT02299687	Seoul National University Hospital	Stomach Ulcer	September 2014	Phase 1
NCT04028466	St. Luke´s Medical Center, Philippines	GERD\|Gastro Esophageal Reflux	May 26, 2019	Phase 4
NCT00634114	AstraZeneca	Reflux Esophagitis	January 2008	Phase 3
NCT01159145	AstraZeneca	Pharmacodynamics Study	July 2010	Phase 1
NCT03388463	Menoufia University	Critical Illness	May 11, 2016	Not Applicable
NCT00719420	University of North Texas Health Science Center\|Universidad del Valle, Colombia\|Vanderbilt University	Helicobacter Pylori Infection	April 2006	Phase 3
NCT00492622	University of Louisville\|Bausch Health Americas, Inc.	Gastroparesis\|Gastroesophageal Reflux Disease	June 2007	Phase 4
NCT03327051	Stanford University	Probiotics	March 20, 2018	Phase 4
NCT01762644	Perle Bioscience, Inc.\|Syreon Corporation	Type 1 Diabetes	August 2015	Phase 3
NCT03378960	Emilio Vargas Castrillón\|Fundación Mutua Madrileña\|Hospital San Carlos, Madrid	Bariatric Surgery Candidate	October 31, 2014	Phase 4
NCT03561233	Khon Kaen University\|Thai Rheumatism Association	Systemic Sclerosis\|Gastroesophageal Reflux\|Proton Pubm Inhibitor	May 2013	Phase 1
NCT02182336	Boehringer Ingelheim	Healthy	June 2008	Phase 1
NCT01269333	Hadassah Medical Organization	Drug Interaction of Clopidogrel	January 2011	Phase 1
NCT02226783	Ardelyx	Healthy Volunteers Food Interaction Study	March 2013	Phase 1
NCT01045434	Dr. Reddy´s Laboratories Limited	Healthy	December 2006	Phase 1
NCT00001191	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Institutes of Health Clinical Center (CC)	Gastrinoma\|Zollinger Ellison Syndrome	February 3, 1983	Phase 2
NCT02249936	Ardelyx\|AstraZeneca	Healthy	February 2013	Phase 1
NCT00290823	National Institute of Allergy and Infectious Diseases (NIAID)	Neurocysticercosis	April 2006	Phase 3
NCT04679948	Boehringer Ingelheim	Healthy	December 21, 2020	Phase 1
NCT02844621	The University of Texas Health Science Center at San Antonio	Healthy Volunteers	May 2016	Early Phase 1
NCT03531762	Merck KGaA, Darmstadt, Germany	Healthy	May 14, 2018	Phase 1
NCT02950259	Providence Health & Services\|Brooklyn ImmunoTherapeutics, LLC	Breast Neoplasm\|Breast Neoplasm, Male\|Triple Negative Breast Cancer	February 9, 2017	Phase 1
NCT00931073	Pfizer\|Medivation, Inc.	Alzheimer´s Disease\|Huntington´s Disease	July 2009	Phase 1
NCT01303445	Boehringer Ingelheim	Healthy	March 2011	Phase 1
NCT04840888	Eli Lilly and Company	Healthy	April 26, 2021	Phase 1
NCT02028234	University of Roma La Sapienza	Coronary Artery Disease	February 2014	Phase 4
NCT02505945	Torax Medical Incorporated	GERD Gastroesophageal Reflux Disease	June 2015	Phase 4
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NCT00003151	European Organisation for Research and Treatment of Cancer - EORTC\|University of Glasgow	Lymphoma	September 1997	Phase 2
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NCT03086070	Children´s Hospital Srebrnjak\|University Hospital Center Sisters of Charity, Zagreb, Croatia\|Belupo	Laryngopharyngeal Reflux\|Chronic Rhinosinusitis (Diagnosis)	January 1, 2010	Phase 4
NCT03028103	Epizyme, Inc.	Diffuse Large B Cell Lymphoma\|Primary Mediastinal Lymphoma\|Mantle Cell Lymphoma\|Advanced Solid Tumor\|Marginal Zone Lymphoma	March 27, 2017	Phase 1
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NCT01323465	Jazz Pharmaceuticals	Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4\|Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Potent Inhibitor of CYP3A4\|Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a CYP2C19 Inhibitor	February 2008	Phase 1
NCT00226044	Rijnstate Hospital\|Erasmus Medical Center	Gastroesophageal Reflux\|Esophageal Atresia\|Hernia, Diaphragmatic	September 2005	Phase 3
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NCT02262169	Dexa Medica Group	Non-Bleeding Peptic Ulcers	October 2014	Phase 3
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NCT05109390	Alexion Pharmaceuticals\|Achillion, a wholly owned subsidiary of Alexion	Healthy	July 27, 2018	Phase 1
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NCT01389401	Faculdade de Ciências Médicas da Santa Casa de São Paulo	Gastroesophageal Reflux Disease (GERD)\|Chronic Laryngitis	January 2009
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Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 340.23 mM ; Need ultrasonic)

H ₂ O : 5.56 mg/mL ( 15.13 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7218 mL	13.6091 mL	27.2183 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.08 mg/mL (5.66 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

Synonyms

1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

1H-Benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, sodium salt

Omeprazole sodium

Omeprazole sodium salt

H 168/68 sodium

Losec Sodium

(±)-Omeprazole sodium salt

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole sodium salt

5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole sodium salt