[CAS NO. 956613-01-7] SB-633825
PRODUCTS SPECIFICATIONS [956613-01-7]
DESCRIPTION [956613-01-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 483.58 |
| Molecular Formula | C28H25N3O3S |
| SMILES | O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2C)C(C)=C1)(C)=O |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK) [1]
In Vitro
SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)
[1]
.
SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 9.62 mg/mL ( 19.89 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0679 mL | 10.3396 mL | 20.6791 mL |
| 5 mM | 0.4136 mL | 2.0679 mL | 4.1358 mL |
| 10 mM | 0.2068 mL | 1.0340 mL | 2.0679 mL |