[CAS NO. 957-68-6] 7-Aminocephalosporanic acid

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PRODUCTS SPECIFICATIONS [957-68-6]

Catalog

HY-B1434

Brand

MCE

CAS

957-68-6

DESCRIPTION [957-68-6]

Overview

MDL	MFCD00005177
Molecular Weight	272.28
Molecular Formula	C10H12N2O5S
SMILES	O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](N)C1=O)O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Biochem Biophys Res Commun. 14 July 2022.

Summary

7-Aminocephalosporanic acid is the core chemical structure for the synthesis of cephalosporin antibiotics , is a potent β-lactamase inhibitor.

IC50 & Target

β-lactam

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H ₂ O : 1.1 mg/mL ( 4.04 mM ; ultrasonic and adjust pH to 14 with NaOH)

Ethanol : 1.1 mg/mL ( 4.04 mM ; Need ultrasonic)

DMF : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6727 mL	18.3634 mL	36.7269 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 1 mg/mL (3.67 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

* All of the co-solvents are available by MCE.

References

[1] Ding JM, et al. Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis. J Bacteriol. 2015 Nov 2;198(2):311-20.

Synonyms

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-amino-8-oxo-, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(hydroxymethyl)-8-oxo-, acetate (ester)

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-amino-8-oxo-, (6R-trans)-

(6R,7R)-3-[(Acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

7-Aminocephalosporanic acid

3-Acetoxymethyl-7β-aminoceph-3-em-4-carboxylic acid

7β-Amino-3-acetoxymethylcephemcarboxylic acid

7-ACA

7-ACS

7-Amino-3-acetoxymethyl-3-cephem-4-carboxylic acid

7β-Aminocephalosporanic acid

3-Acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid

7-Amino-3-acetoxymethyl-Δ³-cephem-4-carboxylic acid

(7R)-7-Aminocephalosporanic acid

3-(Acetoxymethyl)-7-aminocephem-4-carboxylic acid