[CAS NO. 958295-17-5] AGN196996

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PRODUCTS SPECIFICATIONS [958295-17-5]

Catalog

HY-16682

Brand

MCE

CAS

958295-17-5

DESCRIPTION [958295-17-5]

Overview

MDL	MFCD28167794
Molecular Weight	482.32
Molecular Formula	C24H20BrNO5
SMILES	BrC1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC(C(C3=CC=C(C)C=C3)=O)=C1OCC

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 518.33 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0733 mL	10.3666 mL	20.7331 mL
5 mM	0.4147 mL	2.0733 mL	4.1466 mL
10 mM	0.2073 mL	1.0367 mL	2.0733 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (4.31 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

* All of the co-solvents are available by MCE.