[CAS NO. 2988594-85-8] AFM32ahydrochloride
PRODUCTS SPECIFICATIONS [2988594-85-8]
DESCRIPTION [2988594-85-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 517.00 |
| Molecular Formula | C25H30ClFN6O3 |
| SMILES | O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl |
1 Publications Citing Use of MCE
Summary
PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) [1] .
IC50 & Target
Protein Arginine Deiminase 2 (PAD2) [1]
In Vitro
In the target engagement assay, the EC
50
of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells
[1]
.
PAD2-IN-1 (compound 32a; 1-25 μM) hydrochloride treatment strongly inhibits histone H3 citrullination with an EC
50
of 2.7 μM in HEK293T/PAD2 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)