PARL-IN-1
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 734.92 |
| Molecular Formula | C40H58N6O7 |
| SMILES | O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(C(CNCCCCC1=CC=CC=C1)=O)=O)C)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)C(C)C)=O)C |
Summary
IC50 & Target
IC50: 28 nM (PARL) [1]
In Vitro
PARL-IN-1 (compound 5; 5 nM-20 μM) impedes mitochondrial stress-induced cleavage of PGAM by PARL in cells and inhibits the cleavage of overexpressed human PGAM5 in HEK293T cells in a dose-dependent manner
[1]
.
PARL-IN-1 (0.1-30 μM; 8 h; HEK293T cells) stabilizes PINK1 and triggers its alternative cleavage and trafficking in living cells
[1]
.
PARL-IN-1 (5 μM; 22 h; HEK293 T-REx cells) blocks the respiratory chain leading to aberrant reactive oxygen species (ROS) production, activates the PINK1/Parkin pathway
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | HEK293T cells |
| Concentration: | 0.1, 0.3, 1, 3, 10, and 30 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibitd the PARL-cleavage of overexpressed PINK1 in a dose-dependent manner. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.