11R-VIVIT TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 3573.15 |
| Molecular Formula | C147H259N67O36S |
| SMILES | - |
5 Publications Citing Use of MCE
Summary
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells ( NFAT ) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy [1] .
IC50 & Target
NFAT [1]
In Vitro
11R-VIVIT (100 nM) shows a significant reduction of NFAT2 expression in high glucose treated podocytes compared to podocytes treated with normal glucose. 11R-VIVIT attenuates high glucose induced filtration barrier dysfunction of podocytes [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
11R-VIVIT significantly abrogates the increased urinary albumin excretion rates, attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement, partially restores podocyte number, inhibits NFAT2 activation and uPAR expression in glomerular podocytes [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 27.99 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.2799 mL | 1.3993 mL | 2.7987 mL |
| 5 mM | 0.0560 mL | 0.2799 mL | 0.5597 mL |
| 10 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL |