[CAS NO. ]  RS 09 TFA

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PRODUCTS SPECIFICATIONS

Catalog
HY-P1439A
Brand
MCE
CAS
-

DESCRIPTION

Overview

MDL-
Molecular Weight805.80
Molecular FormulaC33H50F3N9O11
SMILESOC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H](N)C)=O)=O)=O)CC3=CNC=N3)=O)C)=O)CC(C)C)=O)CO)=O.O=C(O)C(F)(F)F

For research use only. We do not sell to patients.


Summary

RS 09 TFA is a TLR4 agonist . RS 09 TFA promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. RS 09 TFA acts as an adjuvant in vivo; RS 09 TFA enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 124.10 mM )

H 2 O : ≥ 50 mg/mL ( 62.05 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2410 mL 6.2050 mL 12.4100 mL
5 mM 0.2482 mL 1.2410 mL 2.4820 mL
10 mM 0.1241 mL 0.6205 mL 1.2410 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.10 mM); Clear solution

* All of the co-solvents are available by MCE.