[CAS NO. 9005-32-7] Alginic acid
PRODUCTS SPECIFICATIONS [9005-32-7]
DESCRIPTION [9005-32-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 546.39 |
| Molecular Formula | C18H26O19 |
| SMILES | [C@@H]1([C@@H]([C@@H](C(=O)O)O[C@H]([C@H]1O)O[C@H]2[C@@H]([C@@H]([C@H](O[C@H]3[C@@H]([C@@H]([C@H](O)O[C@H]3C(=O)O)O)O)O[C@H]2C(=O)O)O)O)O)O |
Summary
Alginic acid is a natural polysaccharide, which has been widely concerned and applied due to its excellent water solubility, film formation, biodegradability and biocompatibility. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Alginic acid has an inhibitory effect on histamine release. Anti-anaphylactic and anti-inflammatory properties [1] [2] [3] .
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Alginic acid (AA) is a kind of polysaccharide extracted from brown seaweeds and has been widely used in food industry [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01918410 | Louis Tong|Singapore Eye Research Institute|SEED Company Pte Ltd|Singapore National Eye Centre |
Dry Eyes
|
February 2014 | Not Applicable |
| NCT01878526 | Khon Kaen University |
Gastroesophageal Reflux Disease|Systemic Sclerosis|Scleroderma
|
June 2013 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 3.03 mg/mL ( 5.55 mM ; ultrasonic and adjust pH to 12 with 1M NaOH)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8302 mL | 9.1510 mL | 18.3019 mL |
| 5 mM | 0.3660 mL | 1.8302 mL | 3.6604 mL |
| 10 mM | --- | --- | --- |
References
- [1] Guo X, et al. Structures, properties and application of alginic acid: A review. Int J Biol Macromol. 2020;162:618-628.
- [2] Cui J, et al. Alginic acid induces oxidative stress-mediated hormone secretion disorder, apoptosis and autophagy in mouse granulosa cells and ovaries. Toxicology. 2022;467:153099.
- [3] Jeong HJ, et al. Alginic acid has anti-anaphylactic effects and inhibits inflammatory cytokine expression via suppression of nuclear factor-kappaB activation. Clin Exp Allergy. 2006;36(6):785-794.