[CAS NO. 1982372-88-2] A-196
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PRODUCTS SPECIFICATIONS [1982372-88-2]
Catalog
SLK-S7983
Brand
Selleck
CAS
1982372-88-2
DESCRIPTION [1982372-88-2]
Overview
| MDL | MFCD29924807 |
|---|---|
| Molecular Weight | 359.25 |
| Molecular Formula | C18H16Cl2N4 |
| SMILES | ClC1=CC2=C(C=C1Cl)C(C3=CC=NC=C3)=NN=C2NC4CCCC4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7836 mL | 13.9179 mL | 27.8358 mL |
| 5 mM | 0.5567 mL | 2.7836 mL | 5.5672 mL |
| 10 mM | 0.2784 mL | 1.3918 mL | 2.7836 mL |
| 50 mM | - | - | - |
Description
A-196 is a potent and selective inhibitor of and with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
In vitro
In cells, A-196 induces a global decrease in H4K20me2 and H4K20me3 and a concomitant increase in H4K20me1, but has no effect on any of the other histone modifications. A-196 inhibits 53BP1 foci formation upon ionizing radiation and reduces NHEJ-mediated DNA-break repair but does not affect homology-directed repair. A-196 potently inhibits SUV420H1 and SUV420H2 at both 1 and 10 μM of A-196, but has no activity at either concentration against any of the other PKMTs in the panel, including the other H4K20-modifying enzyme, PR-SET7, and those that utilize H3K4, H3K9, H3K27, and H3K79 as substrates.
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