[CAS NO. 91396-88-2] PluriSIn #1 (NSC 14613)
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PRODUCTS SPECIFICATIONS [91396-88-2]
Catalog
SLK-S8076
Brand
Selleck
CAS
91396-88-2
DESCRIPTION [91396-88-2]
Overview
| MDL | MFCD02344904 |
|---|---|
| Molecular Weight | 213.24 |
| Molecular Formula | C12H11N3O |
| SMILES | O=C(C1=CC=NC=C1)NNC2=CC=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6896 mL | 23.4478 mL | 46.8955 mL |
| 5 mM | 0.9379 mL | 4.6896 mL | 9.3791 mL |
| 10 mM | 0.4690 mL | 2.3448 mL | 4.6896 mL |
| 50 mM | 0.0938 mL | 0.4690 mL | 0.9379 mL |
Description
PluriSIn #1 is an inhibitor of the , which is able to selectively eliminate hPSCs.
Targets
| SCD1 [1] |
In vitro
PluriSIns #1 has a robust, rapid, and selective cytotoxic effect toward hPSCs. Apoptosis is the central cell death mechanism activated by PluriSIn #1. PluriSIn #1 leads to ER stress in hPSCs. PluriSIn #1 (20 μM) induces ~30% decrease in protein synthesis in hPSCs. PluriSIn #1 exposure induces a ~65% decrease in stearoyl-coA desaturase (SCD1) activity in hPSCs. PluriSIn #1 (20 μM) prevents teratoma gormation from undifferentiated hPSCs PluriSIns also inhibits mPSCs and hinders mouse embryonic development.
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