[CAS NO. 1855871-76-9] V-9302

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1855871-76-9]

Catalog

SLK-S8818

Brand

Selleck

CAS

1855871-76-9

DESCRIPTION [1855871-76-9]

Overview

MDL	MFCD32062750
Molecular Weight	538.68
Molecular Formula	C34H38N2O4
SMILES	O=C(O)[C@@H](N)CCN(CC1=CC=CC=C1OCC2=CC=CC(C)=C2)CC3=CC=CC=C3OCC4=CC=CC(C)=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8564 mL	9.2819 mL	18.5639 mL
5 mM	0.3713 mL	1.8564 mL	3.7128 mL
10 mM	0.1856 mL	0.9282 mL	1.8564 mL
50 mM	0.0371 mL	0.1856 mL	0.3713 mL

Description

V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. V-9302 blocks and the as observed in 143B osteosarcoma cells, HCC1806 breast cancer cells and Xenopus laevis oocytes.

Targets

ASCT2 ^[1]
(HEK293 cells)

9.6 μM

In vitro

V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency (IC50 V-9302 = 9.6 µM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 µM).

References

[1] Schulte ML, et al. Nat Med. 2018, 24(2):194-202.
[2] Angelika Bröer, et al. Front Pharmacol . 2018 Jul 19;9:785.