[CAS NO. 736992-21-5] Elamipretide (MTP-131)

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PRODUCTS SPECIFICATIONS [736992-21-5]

Catalog

SLK-S9803

Brand

Selleck

CAS

736992-21-5

DESCRIPTION [736992-21-5]

Overview

MDL	MFCD20133791
Molecular Weight	639.79
Molecular Formula	C32H49N9O5
SMILES	O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCCN)NC([C@H](CC2=C(C)C=C(C=C2C)O)NC([C@@H](CCCNC(N)=N)N)=O)=O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.5630 mL	7.8151 mL	15.6301 mL
5 mM	0.3126 mL	1.5630 mL	3.1260 mL
10 mM	0.1563 mL	0.7815 mL	1.5630 mL
50 mM	0.0313 mL	0.1563 mL	0.3126 mL

Description

Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Targets

cytochrome c peroxidase ^[1]

In vitro

SS-31 binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the SS-31/cardiolipin complex inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.

References

[1] Alexander V Birk, et al. J Am Soc Nephrol. 2013 Jul;24(8):1250-61.
[2] Weixing Zhao, et al. J Neuroinflammation. 2019 Nov 20;16(1):230.